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Toward Fully Synthetic Homogeneous Glycoproteins: A High Mannose Core Containing Glycopeptide Carrying Full H‐Type 2 Human Blood Group Specificity
Author(s) -
Wang ZhiGuang,
Zhang Xufang,
Visser Michael,
Live David,
Zatorski Andrzej,
Iserloh Ulrich,
Lloyd Kenneth O.,
Danishefsky Samuel J.
Publication year - 2001
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20010504)40:9<1728::aid-anie17280>3.0.co;2-1
Subject(s) - glycopeptide , abo blood group system , glycoprotein , homogeneous , blood type (non human) , group (periodic table) , chemistry , biochemistry , biology , immunology , combinatorics , organic chemistry , mathematics , antibiotics
Blood typing with the ABO classification is based on cell‐surface glycoproteins. In a significant step toward the synthesis of these compounds, the laboratory synthesis of a fully functional N‐linked glycopeptide featuring H‐type blood group determinants 1 is described.