Premium
pH‐Responsive Polymer Microspheres: Rapid Release of Encapsulated Material within the Range of Intracellular pH
Author(s) -
Lynn David M.,
Amiji Mansoor M.,
Langer Robert
Publication year - 2001
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20010504)40:9<1707::aid-anie17070>3.0.co;2-f
Subject(s) - polymer , intracellular , chemistry , solubility , microsphere , drug delivery , fluorescence , chemical engineering , intracellular ph , fluorescence microscope , biophysics , nanotechnology , materials science , organic chemistry , biochemistry , physics , quantum mechanics , biology , engineering
Microspheres formed from a new poly( β ‐amino ester) degrade slowly at pH 7.4 (left fluorescence microscopy image) but dissolve quickly at pH values below 6.5 (right), to release encapsulated material rapidly and quantitatively. As the pH/solubility transition occurs within the intracellular pH range, these tiny spheres hold promise as intracellular drug delivery vehicles.