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The Biosynthesis of Vancomycin‐Type Glycopeptide Antibiotics—New Insights into the Cyclization Steps
Author(s) -
Bischoff Daniel,
Pelzer Stefan,
Höltzel Alexandra,
Nicholson Graeme J.,
Stockert Sigrid,
Wohlleben Wolfgang,
Jung Günther,
Süssmuth Roderich D.
Publication year - 2001
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20010504)40:9<1693::aid-anie16930>3.0.co;2-8
Subject(s) - glycopeptide , biosynthesis , glycopeptide antibiotic , vancomycin , mutant , antibiotics , microbiology and biotechnology , chemistry , stereochemistry , gene , biology , biochemistry , bacteria , staphylococcus aureus , genetics
A new oxyA gene replacement mutant of Amycolatopsis mediterranei enabled us to isolate two peptides, SP‐1132 ( 1 ) and SP‐1294 ( 2 ), which only have one diaryl ether bridge. These vancomycin‐type structures provide further insight into the oxidative ring‐bridging steps in their biosynthesis.