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Improving Enantioselective Fluorination Reactions: Chiral N ‐Fluoroammonium Salts and Transition Metal Catalysts
Author(s) -
Muñiz Kilian
Publication year - 2001
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20010504)40:9<1653::aid-anie16530>3.0.co;2-w
Subject(s) - enantioselective synthesis , stereocenter , catalysis , nucleophile , epoxide , chemistry , electrophile , electrophilic fluorination , substrate (aquarium) , transition metal , combinatorial chemistry , ligand (biochemistry) , organic chemistry , biochemistry , oceanography , receptor , geology
Enantioselective fluorinations made easier! Chiral N ‐fluoroammonium salts such as A , or chiral catalysts generated from complexes B (L=ligand) broaden the substrate scope for electrophilic fluorination. Starting from prochiral substrates they offer an efficient approach to chiral fluoro derivatives such as C . Additionally, fluorinated stereogenic centers can be generated from nucleophilic, catalytic epoxide opening.