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Expanding the Pyrimidine Diphosphosugar Repertoire: The Chemoenzymatic Synthesis of Amino‐ and Acetamidoglucopyranosyl Derivatives
Author(s) -
Jiang Jiqing,
Biggins John B.,
Thorson Jon S.
Publication year - 2001
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20010417)40:8<1502::aid-anie1502>3.0.co;2-k
Subject(s) - pyrimidine , repertoire , chemistry , thymidine , scheme (mathematics) , uridine , computer science , combinatorial chemistry , stereochemistry , biochemistry , mathematics , rna , art , dna , gene , literature , mathematical analysis
The exploitation of a unique thymidylyltransferase (E p ) allows the rapid syntheses of thymidine and uridine 5′‐(aminodeoxy‐ α ‐ D ‐hexopyranosyl diphosphates), 5′‐(acetamidodeoxy‐ α ‐ D ‐hexopyranosyl diphosphates), and even 5′‐(aminodideoxy‐ α ‐ D ‐hexopyranosyl diphosphates), which are amino analogues of the products from the native reaction of E p (see scheme).