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Synthesis of DNA Oligomers Possessing a Covalently Cross‐Linked Watson–Crick Base Pair Model
Author(s) -
Li HongYu,
Qiu YaoLing,
Moyroud Elisabeth,
Kishi Yoshito
Publication year - 2001
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20010417)40:8<1471::aid-anie1471>3.0.co;2-i
Subject(s) - base pair , antiparallel (mathematics) , molecular structure of nucleic acids: a structure for deoxyribose nucleic acid , dna , covalent bond , base (topology) , chemistry , pairing , oligomer , stereochemistry , crystallography , physics , polymer chemistry , mathematics , biochemistry , organic chemistry , mathematical analysis , quantum mechanics , magnetic field , superconductivity
Building bridges : A feasible solid‐phase synthesis of antiparallel n ‐, h ‐, and H ‐type DNA oligomers (see picture) has been demonstrated. The oligomers possess a CH 2 ‐bridged base‐pair model that should be conformationally flexible, even after base pairing.