Premium
Enantioselective Hydrogen Atom Transfer Reactions: Synthesis of N ‐Acyl‐ α ‐Amino Acid Esters
Author(s) -
Sibi Mukund P.,
Asano Yasutomi,
Sausker Justin B.
Publication year - 2001
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20010401)40:7<1293::aid-anie1293>3.0.co;2-y
Subject(s) - enantioselective synthesis , chemistry , glycine , radical , amino acid , conjugate , hydrogen atom , chiral lewis acid , lewis acids and bases , catalysis , organic chemistry , stereochemistry , medicinal chemistry , combinatorial chemistry , biochemistry , group (periodic table) , mathematical analysis , mathematics
Glycine radicals derived from conjugate radical additions to dehydroalanines complexed to chiral Lewis acids (L*) undergo enantioselective H‐atom transfer to furnish α ‐amino acids (see scheme). A variety of amino acids with ee values ranging from 27–85 % can be prepared with good chemical efficiency.