Premium
Indoloparacyclophanes: Synthesis and Dopamine Receptor Binding of a Novel Arylbioisostere
Author(s) -
Ortner Birgit,
Waibel Reiner,
Gmeiner Peter
Publication year - 2001
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20010401)40:7<1283::aid-anie1283>3.0.co;2-#
Subject(s) - chemistry , dopamine , dopamine receptor , dopamine receptor d2 , receptor , combinatorial chemistry , neuroscience , biochemistry , biology
Fancy drug candidates : The first preparation of indoloparacyclophanes is reported through the use of the Buchwald variant of the Fischer indole synthesis (see scheme). Receptor binding studies clearly demonstrated that the double‐layered molecular scaffold can serve as an effective arylbioisostere.