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Antitumor trans Platinum Complexes can Form Cross‐Links with Adjacent Purine Groups
Author(s) -
Liu Yangzhong,
Pacifico Concetta,
Natile Giovanni,
Sletten Einar
Publication year - 2001
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20010401)40:7<1226::aid-anie1226>3.0.co;2-u
Subject(s) - platinum , nucleic acid , adduct , purine , stereochemistry , chemistry , cisplatin , biochemistry , organic chemistry , biology , genetics , enzyme , catalysis , chemotherapy
1,2‐Intrastrand chelation is not unique for cisplatin adducts of nucleic acids, but is also possible for Pt complexes having a trans geometry. This possibility is demonstrated by the formation of an unprecedented cross‐link of a trans ‐Pt‐iminoether complex ( trans‐EE , see picture) with the A(N3) and G(N7) positions of the ribonucleotide r(ApG).