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Highly Enantioselective or Not?—Chiral Monodentate Monophosphorus Ligands in the Asymmetric Hydrogenation
Author(s) -
Komarov Igor V.,
Börner Armin
Publication year - 2001
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20010401)40:7<1197::aid-anie1197>3.0.co;2-g
Subject(s) - enantioselective synthesis , denticity , rhodium , asymmetric hydrogenation , chemistry , ligand (biochemistry) , derivative (finance) , noyori asymmetric hydrogenation , combinatorial chemistry , stereochemistry , catalysis , organic chemistry , crystal structure , receptor , biochemistry , financial economics , economics
Much better than their reputation are the rhodium( I ) complexes of monophosphorus ligands, which were believed to be unsuitable for use in highly enantioselective hydrogenation reactions and have lain dormant and forgotten for 30 years. Now values of >99 % ee have been reached in the hydrogenation of standard substrates when the ligand used is the binaphthol derivative 1 . As the synthesis of the monodentate ligands is often simpler than that of the more common diphosphorus ligands, a new and promising area of application has been opened up.