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Turning On Cell Migration with Electroactive Substrates
Author(s) -
Yousaf Muhammad N.,
Houseman Benjamin T.,
Mrksich Milan
Publication year - 2001
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20010316)40:6<1093::aid-anie10930>3.0.co;2-q
Subject(s) - cell migration , cell , chemistry , microbiology and biotechnology , biophysics , nanotechnology , materials science , biology , biochemistry
A dynamic surface can “turn on” the migration of adherent cells. This dynamic property is based on a self‐assembled monolayer that presents hydroquinone groups. Electrochemical oxidation converts the hydroquinone into the corresponding benzoquinone, which then undergoes a Diels–Alder reaction with a conjugate of cyclopentadiene and a peptide ligand. This in situ modification of the substrate gives a surface that promotes cell migration (see scheme).