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A New Phase‐Switch Method for Application in Organic Synthesis Programs Employing Immobilization through Metal‐Chelated Tagging
Author(s) -
Ley Steven V.,
Massi Alessandro,
Rodríguez Félix,
Horwell David C.,
Lewthwaite Russell A.,
Pritchard Martyn C.,
Reid Alison M.
Publication year - 2001
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20010316)40:6<1053::aid-anie10530>3.0.co;2-d
Subject(s) - combinatorial chemistry , chelation , metal , phase (matter) , chemistry , metal ions in aqueous solution , bipyridine , organic chemistry , crystal structure
Simple purification of compounds can be achieved using a bipyridine unit as a tag and resin‐bound metal ions. The usefulness of this method (see scheme) is demonstrated by the multistep synthesis of a small library of hydantoins and benzodiazepines.