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Ruthenium‐Catalyzed Regioselective α ‐Alkylation of Ketones: The First Alkyl‐Group Transfer from Trialkylamines to the α ‐C Atom of Ketones
Author(s) -
Cho Chan Sik,
Kim Bok Tae,
Lee Myung Jin,
Kim TaeJeong,
Shim Sang Chul
Publication year - 2001
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20010302)40:5<958::aid-anie958>3.0.co;2-4
Subject(s) - regioselectivity , alkylation , alkyl , ruthenium , catalysis , group (periodic table) , chemistry , medicinal chemistry , ketone , organic chemistry
A new reaction : A ruthenium‐catalyzed transfer of an alkyl group from a trialkylamine to the α ‐carbon atom of a ketone leads in good yields to α ‐alkylated ketones [Eq. (1)]. The reaction is applicable to a wide range of alkyl(alkyl), alkyl(aryl), and cyclic ketones, and in the case of unsymmetrical ketones it takes place regioselectively at the less hindered α ‐position.