Premium
A Direct and Efficient α ‐Selective Glycosylation Protocol for the Kedarcidin Sugar, L ‐Mycarose: AgPF 6 as a Remarkable Activator of 2‐Deoxythioglycosides
Author(s) -
Lear Martin J.,
Yoshimura Fumihiko,
Hirama Masahiro
Publication year - 2001
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20010302)40:5<946::aid-anie946>3.0.co;2-g
Subject(s) - sugar , chemistry , activator (genetics) , potency , glycosylation , computer science , biochemistry , combinatorial chemistry , in vitro , gene
The α ‐selective effect and potency of AgPF 6 on readily prepared 2‐deoxythioglycosides allows the direct attachment of a partially protected allo ‐sugar, such as L ‐mycarose, to an advanced and hindered aglycon unit of kedarcidin (see picture). This method also permits access to other 2‐deoxyglycosides in an expedient and mild manner. PMBM= p ‐methoxybenzyloxymethyl, Alloc=allyloxycarbonyl, TES=triethylsilyl.