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Total Synthesis of the Macrolide Antibiotic 5,6‐Dihydrocineromycin B
Author(s) -
Tietze Lutz F.,
Völkel Ludwig
Publication year - 2001
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20010302)40:5<901::aid-anie901>3.0.co;2-f
Subject(s) - total synthesis , antibiotics , ketone , chemistry , stereochemistry , macrolide antibiotics , methyl ketone , combinatorial chemistry , organic chemistry , biochemistry , erythromycin
Three building blocks are coupled convergently in the first total synthesis of the macrolide antibiotic 5,6‐tetrahydrocineromycin B ( 1 ); the facial selective allylation of a methyl ketone is the key step of the synthesis. TBDMS= tert ‐butyldimethylsilyl, PMB= p ‐methoxybenzyl.