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Intramolecular DNA Coiling Mediated by a Metallo‐Supramolecular Cylinder
Author(s) -
Han Michael J.,
Moreno Virtudes,
Prieto Maria J.,
Moldrheim Erlend,
Sletten Einar,
Meistermann Isabelle,
Isaac Christian J.,
Sanders Karen J.,
Rodger Alison
Publication year - 2001
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20010302)40:5<879::aid-anie879>3.0.co;2-x
Subject(s) - intramolecular force , groove (engineering) , supramolecular chemistry , dna , crystallography , minor groove , cylinder , circular dichroism , materials science , bending , chemistry , stereochemistry , geometry , composite material , mathematics , crystal structure , biochemistry , metallurgy
In the groove! A tetracationic supramolecular cylinder, [Fe 2 L 3 ] 4+ (L=C 25 H 20 N 4 ), with a triple‐helical architecture is just the right size to fit into the major groove of DNA (see picture) and too big to fit into the minor groove. NMR spectroscopic data confirm that the cylinder binds in the major groove. Linear dichroism shows that very low loadings of [Fe 2 L 3 ] 4+ have a dramatic bending effect on the DNA and atomic force microscopy images show that this is an intramolecular effect resulting in coils of DNA.