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A Rh‐Catalyzed C−H Insertion Reaction for the Oxidative Conversion of Carbamates to Oxazolidinones
Author(s) -
Espino Christine G.,
Du Bois J.
Publication year - 2001
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20010202)40:3<598::aid-anie598>3.0.co;2-9
Subject(s) - chemistry , amination , stereospecificity , intramolecular force , catalysis , rhodium , enantiomeric excess , enantiomer , alkane , oxidative phosphorylation , reductive amination , combinatorial chemistry , primary (astronomy) , medicinal chemistry , organic chemistry , enantioselective synthesis , biochemistry , physics , astronomy
Selective intramolecular alkane oxidations: an Rh II carboxylate catalyzed C−H amination reaction facilitates the preparation of 1,2‐amino alcohols from primary carbamates. The reaction is stereospecific, providing access to chiral α ‐branched amines from optically pure starting materials with no loss in enantiomeric excess (see scheme).