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Diastereo‐ and Enantioselective Synthesis of Pyrrolo[1,4]benzodiazepines through Decarboxylative Photocyclization
Author(s) -
Griesbeck Axel G.,
Kramer Wolfgang,
Lex Johann
Publication year - 2001
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20010202)40:3<577::aid-anie577>3.0.co;2-l
Subject(s) - enantioselective synthesis , chemistry , stereochemistry , combinatorial chemistry , organic chemistry , catalysis
Memory of chirality in triplet 1,7‐diradicals was detected for the first time and to a remarkably high degree in the decarboxylative photocyclization of the proline derivative of N ‐phthaloyl anthranilic acid 1 into 2 (X=H: 45 % yield, 86 % ee ; X=Cl: 50 % yield, 79 % ee ).