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Synthesis of Functionalized Cyclohexadiene‐ trans ‐Diols with Recombinant Cells of Escherichia coli
Author(s) -
Franke Dirk,
Sprenger Georg A.,
Müller Michael
Publication year - 2001
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20010202)40:3<555::aid-anie555>3.0.co;2-0
Subject(s) - escherichia coli , recombinant dna , chemistry , microbiology and biotechnology , biology , biochemistry , gene
As valuable chiral building blocks for the syntheses of natural products and pharmacologically active substances, especially of carbohydrate mimetics, functionalized cyclohexadiene‐ trans ‐diols such as (2 S ,3 S )‐dihydroxy‐2,3‐dihydrobenzoic acid ( 1 ) can be prepared easily in 17 % yield starting from glucose by using metabolically deregulated, recombinant microorganisms such as the Escherichia coli strain AN193 (see scheme).