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Engineering Catalysts for Enantioselective Addition of Diethylzinc to Aldehydes with Racemic Amino Alcohols: Nonlinear Effects in Asymmetric Deactivation of Racemic Catalysts
Author(s) -
Long Jiang,
Ding Kuiling
Publication year - 2001
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20010202)40:3<544::aid-anie544>3.0.co;2-8
Subject(s) - diethylzinc , enantioselective synthesis , catalysis , chemistry , alcohol , combinatorial chemistry , organic chemistry
Correct additions make a difference : Asymmetric deactivation and asymmetric amplification concepts coupled with a high‐throughput screening technique provided a successful strategy for designing a highly enantioselective catalytic system by simple combination of a racemic amino alcohol ( rac ‐DB) and a nonracemic additive (AA). The example in the scheme shows the conversion of 1 into 2 with up to 92.7 % ee.