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The Application of L ‐Proline as an Enzyme Mimic and Further New Asymmetric Syntheses Using Small Organic Molecules as Chiral Catalysts
Author(s) -
Gröger Harald,
Wilken Jörg
Publication year - 2001
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20010202)40:3<529::aid-anie529>3.0.co;2-x
Subject(s) - small molecule , catalysis , proline , chemistry , organic molecules , combinatorial chemistry , molecule , enantioselective synthesis , enzyme , organic synthesis , amino acid , enzyme catalysis , organic chemistry , stereochemistry , biochemistry
Can a simple amino acid act like an enzyme? This question is reviewed and discussed herein. In addition, new contributions in which simple organic molecules are used as efficient chiral catalysts in asymmetric synthesis (see scheme) are highlighted.