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An Artificial Ion Channel Formed by a Macrocyclic Resorcin[4]arene with Amphiphilic Cholic Acid Ether Groups
Author(s) -
Yoshino Naomi,
Satake Akiharu,
Kobuke Yoshiaki
Publication year - 2001
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20010119)40:2<457::aid-anie457>3.0.co;2-f
Subject(s) - cholic acid , amphiphile , amphiphilic molecule , ether , bilayer , alkyl , chemistry , molecule , membrane , schematic , ion channel , ion , materials science , polymer chemistry , organic chemistry , bile acid , copolymer , biochemistry , receptor , electronic engineering , engineering , polymer
Tail‐to‐tail assembly of two molecules of a resorcin[4]arene resulted in a bilayer membrane with an intramembrane ion channel (see schematic diagram). The steroidal tails introduced here have the advantages of giving a long‐lived open state of the pore (2.5–4.5 s, as opposed to tens of milliseconds for alkyl tails) and of allowing the hydrophilic pore to be modified without changing the overall structural features.