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Identification and Isolation of a Receptor for N ‐Methyl Alkylammonium Salts: Molecular Amplification in a Pseudo‐peptide Dynamic Combinatorial Library
Author(s) -
Cousins Graham R. L.,
Furlan Ricardo L. E.,
Ng YiuFai,
Redman James E.,
Sanders Jeremy K. M.
Publication year - 2001
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20010119)40:2<423::aid-anie423>3.0.co;2-6
Subject(s) - trifluoroacetic acid , peptide , combinatorial chemistry , chemistry , receptor , isolation (microbiology) , stereochemistry , biochemistry , organic chemistry , bioinformatics , biology
A cyclic pseudo‐peptide receptor for acetylcholine has been amplified and isolated from a dynamic combinatorial library by virtue of templated stabilization under thermodynamic control (see scheme, TFA=trifluoroacetic acid). This is a demonstration of significant molecular amplification in dynamic systems to evolve a novel receptor.