Towards the Development of Antitumor Vaccines: A Synthetic Conjugate of a Tumor‐Associated MUC1 Glycopeptide Antigen and a Tetanus Toxin Epitope | Zendy

Keil Stefanie | Zendy; Claus Christine | Zendy; Dippold Wolfgang | Zendy; Kunz Horst | Zendy

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Towards the Development of Antitumor Vaccines: A Synthetic Conjugate of a Tumor‐Associated MUC1 Glycopeptide Antigen and a Tetanus Toxin Epitope

Author(s) -

Keil Stefanie,

Claus Christine,

Dippold Wolfgang,

Kunz Horst

Publication year - 2001

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/1521-3773(20010119)40:2<366::aid-anie366>3.0.co;2-j

Subject(s) - glycopeptide , epitope , muc1 , tetanus , toxin , conjugate , antigen , medicine , virology , immunology , microbiology and biotechnology , vaccination , biology , antibiotics , mathematical analysis , mathematics

Proliferation of cytotoxic T‐cells , a prerequisite for the development of antitumor vaccines, was induced by 1 , but not by its partial structures A and B . The conjugate 1 containing a tumor‐associated Sialyl–T N –MUC‐1 glycopeptide antigen A and a T‐cell epitope B of tetanus toxin was synthesized by fragment condensation on a solid phase.

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