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Towards the Development of Antitumor Vaccines: A Synthetic Conjugate of a Tumor‐Associated MUC1 Glycopeptide Antigen and a Tetanus Toxin Epitope
Author(s) -
Keil Stefanie,
Claus Christine,
Dippold Wolfgang,
Kunz Horst
Publication year - 2001
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20010119)40:2<366::aid-anie366>3.0.co;2-j
Subject(s) - glycopeptide , epitope , muc1 , tetanus , toxin , conjugate , antigen , medicine , virology , immunology , microbiology and biotechnology , vaccination , biology , antibiotics , mathematical analysis , mathematics
Proliferation of cytotoxic T‐cells , a prerequisite for the development of antitumor vaccines, was induced by 1 , but not by its partial structures A and B . The conjugate 1 containing a tumor‐associated Sialyl–T N –MUC‐1 glycopeptide antigen A and a T‐cell epitope B of tetanus toxin was synthesized by fragment condensation on a solid phase.