Premium
Highly Enantioselective Palladium‐Catalyzed Ene‐Type Cyclization of a 1,6‐Enyne
Author(s) -
Hatano Manabu,
Terada Masahiro,
Mikami Koichi
Publication year - 2001
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20010105)40:1<249::aid-anie249>3.0.co;2-x
Subject(s) - palladium , cationic polymerization , enyne , ene reaction , enantioselective synthesis , catalysis , chemistry , combinatorial chemistry , stereochemistry , medicinal chemistry , organic chemistry
Enantioenriched five‐membered rings with a quaternary chiral center are prepared with remarkable efficiency by the ene‐type carbocyclization of 1,6‐enynes catalyzed by chiral palladium complexes (see scheme). Possible mechanisms including neutral (five‐coordinate) and cationic (four‐coordinate) intermediates have also been proposed.