Premium
A Mass Spectrometric Labeling Strategy for High‐Throughput Reaction Evaluation and Optimization: Exploring C−H Activation
Author(s) -
Szewczyk Jason W.,
Zuckerman Rebecca L.,
Bergman Robert G.,
Ellman Jonathan A.
Publication year - 2001
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20010105)40:1<216::aid-anie216>3.0.co;2-k
Subject(s) - chemistry , electrospray ionization , mass spectrometry , substrate (aquarium) , combinatorial chemistry , chromatography , oceanography , geology
The functional groups and heterocyclic classes known to be compatible with a directed C−H activation with [Ru 3 (CO) 12 ] has been expanded through development of a new substrate screening strategy. Following C−H activation, a library of products is MS‐labeled and rapidly evaluated by positive ion electrospray ionization mass spectrometry (see scheme) to directly identify successful products and their yields.