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How Capillary Electrophoresis Sequenced the Human Genome
Author(s) -
Dovichi Norman J.,
Zhang Jianzhong
Publication year - 2000
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20001215)39:24<4463::aid-anie4463>3.0.co;2-8
Subject(s) - capillary electrophoresis , human genome , genome , dna sequencing , milestone , computational biology , biology , genomics , dna , gene , genetics , microbiology and biotechnology , geography , archaeology
The most recent milestone in the history of science must be the determination of the sequence of the human genome. Capillary electrophoresis is an important tool that has revolutionized DNA sequencing and allowed the completion of the human genome sequencing well ahead of schedule and well under budget. The development of multiple‐capillary versions of the instrument, with a sheath‐flow cuvette for laser‐induced fluorescence detection, has been an important step in the development of this technology.