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Catalytic Enantioselective Fluorination of β ‐Ketoesters
Author(s) -
Hintermann Lukas,
Togni Antonio
Publication year - 2000
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20001201)39:23<4359::aid-anie4359>3.0.co;2-p
Subject(s) - enantioselective synthesis , catalysis , salt (chemistry) , chemistry , organic chemistry , medicinal chemistry
Isolated and crystallized [Ti(TADDOLato)] complexes were used as catalysts for the first catalytic enantioselective (up to 90 % ee ) C−F bond‐forming reaction, the fluorination of β ‐ketoesters with the N ‐fluorotriethylenediammonium salt F‐TEDA [Eq. (1)]. TADDOL=2,2‐dimethyl‐ α , α , α ′, α ′‐tetraaryl‐1,3‐dioxolan‐4,5‐dimethanol.