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Combinatorial Solid‐Phase Synthesis of Multivalent Cyclic Neoglycopeptides
Author(s) -
Wittmann Valentin,
Seeberger Sonja
Publication year - 2000
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20001201)39:23<4348::aid-anie4348>3.0.co;2-x
Subject(s) - chemistry , combinatorial chemistry , phase (matter) , solid phase synthesis , cyclic peptide , side chain , stereochemistry , organic chemistry , peptide , biochemistry , polymer
Conformationally restricted, multivalent cyclic neoglycopeptides, such as 1 , are accessible by a convergent solid‐phase synthesis in which an active carbonate is treated with immobilized cyclopeptides bearing free amino side chains. The libraries of glycoclusters obtainable by this procedure are suited for screening for lectin‐binding properties.