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A Linker Scaffold to Present Dimers of Pharmacophores Prepared by Solid‐Phase Syntheses
Author(s) -
Pattarawarapan Mookda,
Burgess Kevin
Publication year - 2000
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20001201)39:23<4299::aid-anie4299>3.0.co;2-n
Subject(s) - linker , pharmacophore , solid phase synthesis , combinatorial chemistry , chemistry , reagent , macromolecule , scaffold , phase (matter) , stereochemistry , biochemistry , organic chemistry , computer science , peptide , database , operating system
Mimicry or disruption of protein–protein interactions requires the presentation of pharmacophores to match discontinuous sites on the macromolecular surfaces. The linker shown here was designed to achieve this. The orthogonal protecting groups on the linker allow it to be differentially functionalized, then cleaved from the resin using reagents that will not interfere with biological assays. Fmoc=9‐fluorenylmethoxycarbonyl, Boc= tert ‐butoxycarbonyl.