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Complexation of Antimony( III ) by Trypanothione
Author(s) -
Yan Siucheong,
Ding Keyang,
Zhang Li,
Sun Hongzhe
Publication year - 2000
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20001201)39:23<4260::aid-anie4260>3.0.co;2-9
Subject(s) - chemistry , spermidine , conjugate , antimony , leishmania , stereochemistry , coordination sphere , molecule , biochemistry , organic chemistry , mathematics , mathematical analysis , parasite hosting , world wide web , computer science , enzyme
Antimonial antileishmanial drugs may owe their activity to the formation of a 1:1 complex between Sb and trypanothione—a glutathione/spermidine conjugate that is essential for the growth and survival of trypanosomatid protozoan parasites such as Leishmania. On the basis of the MS and 2D NMR data of the complex, a structure is proposed in which a Sb III ion is bound to the S atoms of cysteine residues, and the coordination sphere of Sb is completed by the oxygen atom of a water molecule (O W ; see picture).