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A Palladium‐Catalyzed Synthesis of Amidines from Aryl Halides
Author(s) -
Saluste C. Gustaf,
Whitby Richard J.,
Furber Mark
Publication year - 2000
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20001117)39:22<4156::aid-anie4156>3.0.co;2-b
Subject(s) - palladium , halide , aryl , catalysis , chemistry , combinatorial chemistry , polymer chemistry , organic chemistry , alkyl
Tin‐free three‐component coupling : Palladium‐catalyzed coupling between aryl or heteroaryl bromides, primary or secondary amines, and tert ‐butyl isocyanide gives high yields of pharmaceutically interesting arylamidines [Eq. (1)]. dppf=1,1′‐bis(diphenylphosphanyl)ferrocene; R 1 /R 2 =Bu/H, Ph/H, −(CH 2 ) 4 −.