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Formation of Optically Active Aromatic α ‐Amino Acids by Catalytic Enantioselective Addition of Imines to Aromatic Compounds
Author(s) -
Saaby Steen,
Fang Xiangming,
Gathergood Nicholas,
Jørgensen Karl Anker
Publication year - 2000
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20001117)39:22<4114::aid-anie4114>3.0.co;2-v
Subject(s) - enantioselective synthesis , optically active , catalysis , chemistry , aromatic amino acids , amino acid , organic chemistry , aromatic plants , combinatorial chemistry , biochemistry , biology , botany
Vital to life , α ‐amino acids are the building blocks of peptides, proteins, and many other natural products, and the formation of optically active nonproteinogenic α ‐amino acids is an important research area. A catalytic enantioselective procedure is presented for the synthesis of optically active aromatic α ‐amino acids by addition of N‐protected α ‐imino esters to aromatic compounds in a reaction catalyzed by chiral Lewis acids (see scheme; Pg=protecting group).