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Inorganic Layered Double Hydroxides as Nonviral Vectors
Author(s) -
Choy JinHo,
Kwak SeoYoung,
Jeong YongJoo,
Park JongSang
Publication year - 2000
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20001117)39:22<4041::aid-anie4041>3.0.co;2-c
Subject(s) - layered double hydroxides , hydroxide , cationic polymerization , biomolecule , oligonucleotide , dna , chemistry , double stranded , dissolution , combinatorial chemistry , materials science , nanotechnology , inorganic chemistry , biochemistry , polymer chemistry , organic chemistry
A biomolecular–inorganic hybrid is formed from anionic biomolecules (such as DNA fragments, ATP, or an antisense oligonucleotide) intercalated in a cationic Mg/Al layered double hydroxide (see picture). Such a hybrid can be used to deliver drugs or genes from the inorganic noncytotoxic carrier. Cellular uptake experiments confirm this, with the carrier dissolving slowly in a leukemia cell, and thereby releasing its growth‐inhibiting load.