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Self‐Repairing DNA Based on a Reductive Electron Transfer through the Base Stack
Author(s) -
Schwögler Anja,
Burgdorf Lars T.,
Carell Thomas
Publication year - 2000
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20001103)39:21<3918::aid-anie3918>3.0.co;2-6
Subject(s) - pyrimidine dimer , stack (abstract data type) , flavin group , dna , electron transfer , schematic , chemistry , base pair , base (topology) , photochemistry , pyrimidine , lesion , electron , dna damage , stereochemistry , physics , computer science , biochemistry , enzyme , medicine , engineering , mathematics , electronic engineering , psychiatry , programming language , mathematical analysis , quantum mechanics
Cycloreversion of the highly mutagenic UV‐induced cyclobutane pyrimidine dimer lesion in DNA occurs by a light‐induced transfer of an electron through the base stack from a flavin electron donor to the lesion (see schematic representation). This process is even effective when the DNA lesion and flavin donor are separated by an intervening base pair.