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Control of Xanthine Oxidase Activity by Light
Author(s) -
Tai Lin Ai,
Hwang Kuo Chu
Publication year - 2000
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20001103)39:21<3886::aid-anie3886>3.0.co;2-a
Subject(s) - xanthine oxidase , allopurinol , xanthine oxidase inhibitor , substrate (aquarium) , chemistry , enzyme , biochemistry , medicine , biology , ecology
Turning the light on and off can control the activity of xanthine oxidase (XOD) when allopurinol ( 1 ) is the substrate. Alloxanthine ( 2 ) is formed in the reaction but also acts as an inhibitor of the enzyme. Irradiation can free the active site and let the enzyme get on with its job. This alloxanthin–XOD system might have important future applications as a photoswitch/integrator in molecular‐scale optobioelectronic devices.