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Novel Oligosaccharide Binding to the Cerium( IV ) Bis(porphyrinate) Double Decker: Effective Amplification of a Binding Signal through Positive Homotropic Allosterism
Author(s) -
Sugasaki Atsushi,
Ikeda Masato,
Takeuchi Masayuki,
Shinkai Seiji
Publication year - 2000
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20001103)39:21<3839::aid-anie3839>3.0.co;2-2
Subject(s) - chemistry , oligosaccharide , cerium , stereochemistry , aqueous solution , binding site , biophysics , crystallography , biochemistry , inorganic chemistry , organic chemistry , biology
The effective binding of oligosaccharides with large association constants ( K =10 5 –10 6 M −2 ) is achieved with the novel scaffold 1 . The binding takes place in aqueous media according to a positive homotropic allosterism to form 1:2 1 :saccharide complexes.