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The Influence of Mismatches on Long‐Distance Charge Transport through DNA
Author(s) -
Giese Bernd,
Wessely Stefan
Publication year - 2000
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20001002)39:19<3490::aid-anie3490>3.0.co;2-s
Subject(s) - guanine , charge (physics) , dna , cytosine , cleavage (geology) , base pair , chemical physics , chemistry , electron transport chain , biophysics , crystallography , physics , biology , nucleotide , biochemistry , quantum mechanics , gene , paleontology , fracture (geology)
The role of relay station is adopted by the guanine bases over which the positive charge is distributed during long‐distance charge transport through DNA. Mismatches at guanine:cytosine (G:C) base pairs reduce the efficiency of charge transport through DNA drastically. The picture shows the histogram of the cleavage products P G and P GGG of a 54‐mer, from which only the decisive sequence segment is depicted.