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Asymmetric, Catalytic Phenyl Transfer to Aldehydes: Enantioselective Synthesis of Diarylmethanols
Author(s) -
Bolm Carsten,
Hermanns Nina,
Hildebrand Jens P.,
Muñiz Kilian
Publication year - 2000
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20001002)39:19<3465::aid-anie3465>3.0.co;2-4
Subject(s) - enantioselective synthesis , catalysis , chemistry , combinatorial chemistry , transfer hydrogenation , organic chemistry , stereochemistry , ruthenium
Excellent enantioselectivities have been achieved in catalyzed asymmetric phenyl transfers to aldehydes (see scheme). In the case of aromatic substrates, the resulting chiral diarylmethanols are valuable precursors for biologically and pharmaceutically interesting compounds.