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Octahedral Grignard Reagents Can Be Chiral at Magnesium
Author(s) -
Vestergren Marcus,
Gustafsson Björn,
Davidsson Öjvind,
Håkansson Mikael
Publication year - 2000
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20001002)39:19<3435::aid-anie3435>3.0.co;2-a
Subject(s) - reagent , magnesium , octahedron , denticity , chemistry , grignard reagent , ligand (biochemistry) , combinatorial chemistry , organic chemistry , crystal structure , receptor , biochemistry
Bidentate ligands and appropriate R groups are the key to preparing six‐coordinate Grignard reagents (see picture). The process is easier still if performed in a solvent, such as dimethoxyethane, that can act as such a ligand. For these complexes, the magnesium center may be chiral and, when acting as a reagent, the complex should give a strong asymmetric induction.