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Linear Coupling of Three CO Ligands of Chromium Hexacarbonyl Leading to Functionalized Butenolides via Fischer Carbene Complexes
Author(s) -
Rudler Henri,
Parlier Andrée,
Certal Victor,
Vaissermann Jacqueline
Publication year - 2000
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20001002)39:19<3417::aid-anie3417>3.0.co;2-2
Subject(s) - carbene , chromium , chemistry , alkoxy group , dihydropyridine , medicinal chemistry , stereochemistry , combinatorial chemistry , organic chemistry , catalysis , alkyl , calcium
Up to three CO ligands of [Cr(CO) 6 ] can be incorporated in a linear fashion as functional groups of butenolides via alkynyl(alkoxy)carbene complexes of chromium. The key step is the biomimetic reduction of the carbene group with N ‐methyl dihydropyridine [Eq. (1)], which induces the cascade insertions of the triple bond and of two CO groups.