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Is Hydrogen Tunneling Involved in AcylCoA Desaturase Reactions? The Case of a Δ 9 Desaturase That Transforms ( E )‐11‐Tetradecenoic Acid into ( Z , E )‐9,11‐Tetradecadienoic Acid
Author(s) -
Abad José Luís,
Camps Francisco,
Fabriàs Gemma
Publication year - 2000
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20000915)39:18<3279::aid-anie3279>3.0.co;2-g
Subject(s) - chemistry , deuterium , hydrogen , hydrogen atom , cleavage (geology) , stearoyl coa desaturase , enzyme , stereochemistry , biochemistry , organic chemistry , biology , gene , physics , gene expression , atomic physics , paleontology , alkyl , fracture (geology)
Desaturation of the title acid , by an iron‐containing desaturase enzyme, occurs in two steps as shown in the scheme. Deuterium labeling experiments show that tunneling of the hydrogen atom contributes to the transfer of hydrogen in the C9−H cleavage step.