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Asymmetric Alkylation of Nitroalkanes
Author(s) -
Trost Barry M.,
Surivet JeanPhilippe
Publication year - 2000
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20000901)39:17<3122::aid-anie3122>3.0.co;2-8
Subject(s) - nitromethane , desymmetrization , alkylation , chemistry , enantioselective synthesis , diol , organic chemistry , catalysis
Cyclic meso ‐2‐ene‐1,4‐diol diesters undergo desymmetrization and cycloalkenyl esters undergo dynamic kinetic asymmetric transformations with excellent enantioselectivity when nitromethane and 2‐nitropropane are used in the reaction (see scheme). A short synthesis of carbanucleosides also emerges.