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The First Solid‐Phase Synthesis of a Peptide‐Tethered Platinum( II ) Complex
Author(s) -
Robillard Marc S.,
Valentijn A. Rob P. M.,
Meeuwenoord Nico J.,
van der Marel Gijs A.,
van Boom Jacques H.,
Reedijk Jan
Publication year - 2000
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20000901)39:17<3096::aid-anie3096>3.0.co;2-d
Subject(s) - tripeptide , platinum , combinatorial chemistry , solid phase synthesis , peptide synthesis , peptide , chemistry , phase (matter) , stereochemistry , organic chemistry , biochemistry , catalysis
Assembly of an immobilized tripeptide , platination, and subsequent deprotection and release from the solid support are the key steps in the solid‐phase peptide synthesis of the peptide–platinum( II ) complex 1 . This new methodology should be applicable for the preparation of a library of platinum antitumor compounds by a combinatorial synthesis approach.