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Asymmetric Synthesis of a Chiral Secondary Grignard Reagent
Author(s) -
Hoffmann Reinhard W.,
Hölzer Bettina,
Knopff Oliver,
Harms Klaus
Publication year - 2000
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20000901)39:17<3072::aid-anie3072>3.0.co;2-4
Subject(s) - stereocenter , reagent , chemistry , grignard reagent , carbon atom , combinatorial chemistry , metal , stereochemistry , atom (system on chip) , enantioselective synthesis , organic chemistry , catalysis , ring (chemistry) , computer science , embedded system
A chiral Grignard reagent with the metal‐bearing carbon atom as the sole stereogenic center has been generated by asymmetric synthesis in >90 % ee (see scheme). Such reagents allow the elucidation of the stereochemical course of subsequent reactions (such as the shown oxidation), which provides hints to the mechanism (electron transfer reactions or polar additions).