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New Strategies for the Development of an Asymmetric Version of the Baylis–Hillman Reaction
Author(s) -
Langer Peter
Publication year - 2000
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20000901)39:17<3049::aid-anie3049>3.0.co;2-5
Subject(s) - baylis–hillman reaction , chemistry , enantioselective synthesis , methylene , organic chemistry , combinatorial chemistry , catalysis
The development of an efficient, asymmetric variant of the Baylis–Hillman reaction for the synthesis of enantiomerically pure α ‐methylene‐ β ‐hydroxycarbonyl compounds (see scheme) is still a very rewarding goal. Interesting recent approaches for the solution of this problem include the use of chiral auxiliaries and bases and the thorough optimization of reaction conditions.