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Stable and Selective Hybridization of Oligonucleotides with Unnatural Hydrophobic Bases
Author(s) -
Berger Markus,
Ogawa Anthony K.,
McMinn Dustin L.,
Wu Yiqin,
Schultz Peter G.,
Romesberg Floyd E.
Publication year - 2000
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20000818)39:16<2940::aid-anie2940>3.0.co;2-#
Subject(s) - oligonucleotide , chemistry , combinatorial chemistry , stereochemistry , biochemistry , dna
Relying on only interbase hydrophobic packing for bonding, several unnatural nucleobases similar to 1 can form selective and stable self‐pairs in duplex DNA. These unnatural nucleobases should make it possible to increase the stringency and information content of hybridization or encoding experiments.