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Cyclization of Terminal Diynes Catalyzed by Thiolate‐Bridged Diruthenium Complexes: A Simple Synthetic Route to endo ‐Macrocyclic ( Z )‐1‐En‐3‐ynes
Author(s) -
Nishibayashi Yoshiaki,
Yamanashi Masashi,
Wakiji Issei,
Hidai Masanobu
Publication year - 2000
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20000818)39:16<2909::aid-anie2909>3.0.co;2-r
Subject(s) - catalysis , chemistry , stereochemistry , terminal (telecommunication) , medicinal chemistry , combinatorial chemistry , organic chemistry , computer science , telecommunications
The thiolate‐bridged diruthenium complexes [Cp*RuCl( μ 2 ‐SR) 2 RuCp*Cl] (Cp*= η 5 ‐C 5 Me 5 ; R=Me, Et, n Pr) have been found to be effective catalysts for the cyclization of α , ω ‐diynes to produce the corresponding endocyclic ( Z )‐1‐en‐3‐ynes in moderate to high yields with complete stereoselectivities (see scheme).