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The First Low Molecular Weight Antibiotic from Lactic Acid Bacteria: Reutericyclin, a New Tetramic Acid
Author(s) -
Höltzel Alexandra,
Gänzle Michael G.,
Nicholson Graeme J.,
Hammes Walter P.,
Jung Günther
Publication year - 2000
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20000804)39:15<2766::aid-anie2766>3.0.co;2-g
Subject(s) - lactic acid , bacteria , antibiotics , microbiology and biotechnology , chemistry , biochemistry , biology , genetics
The first chemical proof is available to show that lactic acid bacteria, generally known for their limited metabolite spectrum, are able to produce antibiotics with a broad inhibitory spectrum. The new tetramic acid, reutericyclin ( 1 ), opens a new dimension in the discussion regarding the application of lactic acid bacteria in food preservation or for positively influencing the human intestinal microflora.