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Fatty Acid‐Oligo(ethylene glycol) Ester Forms Ion Channels in Lipid Membranes
Author(s) -
Renkes Tanja,
Schäfer Hans J.,
Siemens Peter M.,
Neumann Eberhard
Publication year - 2000
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20000717)39:14<2512::aid-anie2512>3.0.co;2-l
Subject(s) - ethylene glycol , membrane , chemistry , vesicle , fatty acid , organic chemistry , biochemistry
The channel activity of ion‐channel‐forming compounds , such as 1 , was assessed by single ion‐current events of planar lipid membranes (see the current–time trace) and, in addition, by fluorescence emission of pyranine in lipid vesicles. These compounds are prepared in two steps from oligo(ethylene glycol) and fatty acids. The modular synthesis of 1 allows simple variations in the head group, the length of the ethylene glycol chain, and the balance between the hydrophobic and hydophilic components.